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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.

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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.

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In 1844, Charles Goodyear obtained the first patent for a rubber condom.

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Alcohol acts as a diuretic. Eight ounces of water is needed to metabolize just 1 ounce of alcohol.

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Signs and symptoms that may signify an eye tumor include general blurred vision, bulging eye(s), double vision, a sensation of a foreign body in the eye(s), iris defects, limited ability to move the eyelid(s), limited ability to move the eye(s), pain or discomfort in or around the eyes or eyelids, red or pink eyes, white or cloud spots on the eye(s), colored spots on the eyelid(s), swelling around the eyes, swollen eyelid(s), and general vision loss.

The four ways in which animals exchange heat with the environment are radiation, evaporation, convec The four ways in which animals exchange heat with the environment are radiation, evaporation, convec
The Environment Influences Gene Expression The Environment Influences Gene Expression
Age and Grammatical Knowledge The challenge of learning a second language rises with age. Source: J Age and Grammatical Knowledge The challenge of learning a second language rises with age. Source: J
Caregivers’ responses sometimes help a child with strong emotions adapt to the environment. Caregivers’ responses sometimes help a child with strong emotions adapt to the environment.
The social movement that centers on the environment has become global. In all nations, people are ... The social movement that centers on the environment has become global. In all nations, people are ...
Economic activity as viewed by environment and ecological economists Economic activity as viewed by environment and ecological economists
Video: Definition of heart rate

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