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In 1864, the first barbiturate (barbituric acid) was synthesized.

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Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.

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The FDA recognizes 118 routes of administration.

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Barbituric acid, the base material of barbiturates, was first synthesized in 1863 by Adolph von Bayer. His company later went on to synthesize aspirin for the first time, and Bayer aspirin is still a popular brand today.

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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.

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