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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.

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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.

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Approximately one in four people diagnosed with diabetes will develop foot problems. Of these, about one-third will require lower extremity amputation.

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Opium has influenced much of the world's most popular literature. The following authors were all opium users, of varying degrees: Lewis Carroll, Charles, Dickens, Arthur Conan Doyle, and Oscar Wilde.

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Vaccines prevent between 2.5 and 4 million deaths every year.

These young children are taking the initiative to explore their environment as they examine a snail These young children are taking the initiative to explore their environment as they examine a snail
Adults in late adulthood may need to adapt to a new environment as they age and their health status Adults in late adulthood may need to adapt to a new environment as they age and their health status
Environment Environment
Shope’s Model of Young Driver Crash Risks The model shows that many factors contribute to crash ris Shope’s Model of Young Driver Crash Risks The model shows that many factors contribute to crash ris
Metamorphic Grade "الصخور المتحولة" Metamorphic Grade "الصخور المتحولة"
A police record search of 250 incoming Grade 10 at a Secondary School shows that 26 had been ... A police record search of 250 incoming Grade 10 at a Secondary School shows that 26 had been ...
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