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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Each year in the United States, there are approximately six million pregnancies. This means that at any one time, about 4% of women in the United States are pregnant.
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This year, an estimated 1.4 million Americans will have a new or recurrent heart attack.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.