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The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
In 1864, the first barbiturate (barbituric acid) was synthesized.
After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.
In 1844, Charles Goodyear obtained the first patent for a rubber condom.
During pregnancy, a woman is more likely to experience bleeding gums and nosebleeds caused by hormonal changes that increase blood flow to the mouth and nose.