Homework Clinic

Science Clinic => Health Science => Topic started by: dakota nelson on Aug 28, 2021

Title: In childhood neuroblastoma, the N-myc oncogene undergoes which type of mutation of normal gene to oncogene?
Post by: dakota nelson on Aug 28, 2021

Question 1

Burkitt lymphomas designate a chromosome that has a piece of chromosome 8 fused to a piece of chromosome 14. This is an example of which mutation of normal genes to oncogenes?

◦ Point mutation
◦ Chromosome translocation
◦ Gene amplification
◦ Chromosome fusion

Question 2

In childhood neuroblastoma, the N-myc oncogene undergoes which type of mutation of normal gene to oncogene?

◦ Point mutation
◦ Chromosome fusion
◦ Gene amplification
◦ Chromosome translocation

Title: In childhood neuroblastoma, the N-myc oncogene undergoes which type of mutation of normal gene to oncogene?
Post by: tofugiraffe on Aug 28, 2021

Answer 1

Chromosome translocation

Chromosome translocations, in which a piece of one chromosome is translocated to another chromosome, can activate oncogenes. One of the best examples is the t(8;14) translocation found in many Burkitt lymphomas; t(8;14) designates a chromosome that has a piece of chromosome 8 fused to a piece of chromosome 14. A point mutation is the alteration of one or a few nucleotide base pairs. Gene amplification is the result of repeated duplication of a region of a chromosome, so that instead of the normal two copies of a gene, tens or even hundreds of copies are present. Chromosome fusion occurs during translocation.

Answer 2

Gene amplification

Amplifications are the result of the duplication of a small piece of a chromosome over and over again; consequently, instead of the normal two copies of a gene, tens or even hundreds of copies are present. The N-myc oncogene is amplified in 25% of childhood neuroblastoma.