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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.

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ACTH levels are normally highest in the early morning (between 6 and 8 A.M.) and lowest in the evening (between 6 and 11 P.M.). Therefore, a doctor who suspects abnormal levels looks for low ACTH in the morning and high ACTH in the evening.

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There are approximately 3 million unintended pregnancies in the United States each year.

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Earwax has antimicrobial properties that reduce the viability of bacteria and fungus in the human ear.

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Women are 50% to 75% more likely than men to experience an adverse drug reaction.

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