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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).

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Signs of depression include feeling sad most of the time for 2 weeks or longer; loss of interest in things normally enjoyed; lack of energy; sleep and appetite disturbances; weight changes; feelings of hopelessness, helplessness, or worthlessness; an inability to make decisions; and thoughts of death and suicide.

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By definition, when a medication is administered intravenously, its bioavailability is 100%.

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After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.

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Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.

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