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In 1864, the first barbiturate (barbituric acid) was synthesized.

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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.

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In 1844, Charles Goodyear obtained the first patent for a rubber condom.

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More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.

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To combat osteoporosis, changes in lifestyle and diet are recommended. At-risk patients should include 1,200 to 1,500 mg of calcium daily either via dietary means or with supplements.

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