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In 1886, William Bates reported on the discovery of a substance produced by the adrenal gland that turned out to be epinephrine (adrenaline). In 1904, this drug was first artificially synthesized by Friedrich Stolz.

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Malaria was not eliminated in the United States until 1951. The term eliminated means that no new cases arise in a country for 3 years.

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This year, an estimated 1.4 million Americans will have a new or recurrent heart attack.

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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.

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Approximately one in four people diagnosed with diabetes will develop foot problems. Of these, about one-third will require lower extremity amputation.

International Performance in Reading, Math, and Science, Eight Grade International Performance in Reading, Math, and Science, Eight Grade
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