Explain why patients with HS sometimes suffer from gallstones. ...

[ahriuashd]

Explain why patients with HS sometimes suffer from gallstones.
 
  What will be an ideal response?

Question 2

Predict the results of the following tests in: HS, HE, HPP, PNH, and OHS.
 
  a. Ham and sucrose lysis tests
  b. Osmotic fragility
  c. Immunophenotyping
  d. Intracellular ion concentration
 
  What will be an ideal response?

[vboyd24]

Answer to Question 1

Answer: Spherocytes in peripheral circulation cause bilirubinemia that subsequently causes bilirubin buildup. Excessive bilirubin production leads to the formation of gallstones.

Answer to Question 2

Answer: Ham and sucrose lysis tests: PNH: increased lysis; HS, HE, HPP, and OHS: normal lysis
Osmotic fragility: HS, HPP, and OHS: increased osmotic fragility; HE, and PNH: normal osmotic fragility
Immunophenotyping: PNH: CD55 and CD59: low intensity staining; HS, HE, HPP, and OHS: normal immunophenotyping
Intracellular ion concentration: OHS: increased intracellular sodium; HS, HE, HPP, and PNH: normal intracellular ion concentration