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Hippocrates noted that blood separates into four differently colored liquids when removed from the body and examined: a pure red liquid mixed with white liquid material with a yellow-colored froth at the top and a black substance that settles underneath; he named these the four humors (for blood, phlegm, yellow bile, and black bile).

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Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.

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In 1864, the first barbiturate (barbituric acid) was synthesized.

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The FDA recognizes 118 routes of administration.

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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.

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