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The B-complex vitamins and vitamin C are not stored in the body and must be replaced each day.

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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.

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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.

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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.

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Though Candida and Aspergillus species are the most common fungal pathogens causing invasive fungal disease in the immunocompromised, infections due to previously uncommon hyaline and dematiaceous filamentous fungi are occurring more often today. Rare fungal infections, once accurately diagnosed, may require surgical debridement, immunotherapy, and newer antifungals used singly or in combination with older antifungals, on a case-by-case basis.

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