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The average adult has about 21 square feet of skin.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
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Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.