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| Description: Neural death was prevented and early spongiosis was reversed in scrapie-infected mice after a genetically engineered enzyme began to destroy PrPc at twelve weeks of age. Arrows point to degenerating neurons in mice without the prion-destroying enzyme. Spongiosis is seen as holes in the brain tissue. (From Mallucci, G., Dickinson, A., Linehan, J., et al. Science, 2003, 302, 871–874. Copyright 2003 by the American Association for the Advancement of Science. Reprinted with permission.)
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