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| Description: The photographs show three patients with hereditary leptin deficiency before (a) and after (b) treatment with leptin for 18 months. The faces of the patients are obscured for privacy. Two normal-weight nurses are shown for comparison purposes. (From Licinto, J., Caglayan, S., Ozata, M., et al. Proceedings of the National Academy of Science, USA, 2004, 101, 4531–4536.)
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