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| Description: Absorption of a drug through cell membranes into the bloodstream (systemic circulation). The drug has to go through many tissue-blood barriers to get to the final site of action. The tissue-blood and blood-tissue barriers are: After swallowing a drug, it goes from the GI tract (gut or small intestine) into the blood (I), then from the blood through the blood-tissue barrier (II) to the site of action (organ or tissue) (III). D, drug; C, carrier.
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