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Stage 2: Synthesis of Squalene from Mevalonate

Stage 2: Synthesis of Squalene from Mevalonate
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Description: The next several reactions occur in the cytosol.

First, mevalonate is activated by three successive phosphorylations.

The first two are simple nucleophilic substitutions on the g-phosphorous of ATP.

The third phosphorylation, at position 3, sets the stage for a decarboxylation to give the five-carbon isopentenyl pyrophosphate

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