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| Description: If heme levels fall, the heme-controlled kinase becomes active and phosphorylates eIF2 (red arrow). This blocks further translation by tying this factor into a stable complex with eIF2B. When heme levels are adequate, the kinase is inhibited, and eIF2 is available for translation initiation. Picture Stats: Views: 389 Filesize: 38.41kB Height: 228 Width: 490 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=35153 |