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| Description: TABLE 19.1 Some Prom-oncogenes and Tumor-Suppressor Genes Prom-oncogene Crmyc c-kit RARa E6 Cyclins Tu mar-Suppressor RB1 APC p53 BRCA 7, BRCAZ Normal Function Transcription factor, regulates cell cycle, differentiation, apoptosis Tyrosine kinase, signal transduction Hormone-dependent transcription factor, differentiation Human papillomavirus encoded oncogene, inactivates p53 Bind to CDKs, regulate cell cycle Normal Function Cell-cycle checkpoints, binds E2F Cellrcell interaction Transcription regulation DNA repair Alteration in Cancer Translocation, amplification, point mutations Mutation Chromosomal translocations with PML gene, fusion product HPV infection Gene amplification, overexpression Alteration in Cancer Mutation, deletion, inactivation by viral oncogene products Mutation Mutation, deletion, viruses Point mutations Associated Cancers Lymphomas, leukemias, lung cancer, many types Sarcomas Acute promyelocytic leukemia Cervical cancer Lung, esophagus, many types Associated Cancers Retinoblastoma, osteosarcoma, many types Colorectal cancers, brain, thyroid Many types Breast, ovarian, prostate cancers Picture Stats: Views: 162 Filesize: 170.96kB Height: 646 Width: 1402 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=44239 |