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| Description: (a) (b) Bicoid protein 0 ‘ ‘ hunchback Bicoid binding SItes gene Posterior - - ::-i If Bicoid protein binding directly l activates hunchback transcription. ‘ Regulatory interactions with l coordinate genes help define l hunchback expression domain. Anterior hunchback expression Maternally supplied mRNA in embryo Biwid adivates Nanos represses ():!:!:2£— hunchback translation of transcription hunchback mRNA Hunchback :::!__|:_ ( 'Successive deletions H of Bicoid binding sites Protein expression in early embryo result In progressive ‘ loss of hunchback mRNA expression.
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