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| Description: (a) Mesenchyme Anterior Posterior Anterior . Posterior osterior 4 Anterior , Posterior 2 2 3 3 Shh from ZPA is at highest Shh promotes both growth Transpiantation of a second ZPA anteriorly results concentration posteriorly. and identity of digits. in mirror-image dupiication of digits. (c) Hox gene clusters Anterior Posterior lab Pb Dfd Scr An be abdA Ade Drosophila IE-I-fljfi-I-I-Z Hoxai Hova Hoxa3 Hoxa4 Hoan Hoxa6 Hoxa7 Hoxa9 Hoxa10 Hoxafl Hoxa13 Human Hoxb1 Hobe Hoxb3 Hoxb4 Hobe Hobe Hoxb7 Hoxb8 Hoxb9 Hoxc4 Hoxc5 Hoxc6 Hoxc8 Hoxc9 Hoxdo Hoxc11 Hoxc12 Hoxc13 :m Hoxdi Hode’ Hoxd4 HoxoB Hoxd9 HodeOHode Hoxd12Hoxd13 I I I I I ‘ Hoxd9, 1o, 11, 12 + 13 Hoxd9, 10, 11 + 12 Hoxd9 I Hoxd9, + '0 I 10 + 11 Anterior Posterior
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