Answer to Question 1
Correct Answer: 4
Rationale 1: The tetracyclines do not carry the greatest risk for allergic response.
Rationale 2: The aminoglycosides do not carry the greatest risk for allergic response.
Rationale 3: The cephalosporins do not carry the greatest risk for allergic response.
Rationale 4: The penicillins are the group of antibiotics that have the highest incidence of allergic reactions.
Global Rationale: Although not common, serious hypersensitivity reactions to antibiotics may be fatal. The penicillins are the class of antibacterials that have the highest incidence of allergic reactions: Between 0.7 and 10 of all patients who receive these drugs exhibit some degree of hypersensitivity.
Answer to Question 2
Correct Answer: 3
Rationale 1: There is no indication that this drug is not safe for those over 20.
Rationale 2: Tetracycline is a broad-spectrum antibiotic.
Rationale 3: The drug is not safe for pregnant women as it can cross the placental barrier and cause mottling of the infant's teeth.
Rationale 4: This drug is used to treat specific types of infections.
Global Rationale: Some antibiotics are readily secreted in breast milk or cross the placenta. For example, tetracyclines taken by the mother can cause teeth discoloration in the newborn, and aminoglycosides can affect hearing. Some anti-infectives are pregnancy category D, such as minocycline, doxycycline, neomycin, and streptomycin.
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