Answer to Question 1
ANS: B
Aminoglycoside-induced nephrotoxicity usually manifests as acute tubular necrosis. Prominent symptoms are proteinuria, casts in the urine, production of dilute urine, and elevations in the serum creatinine and BUN.
Resolution of infection results in a decrease in the white blood cell count.
The BUN is increased, not decreased, with aminoglycoside-induced nephrotoxicity.
The urine is dilute, not concentrated, with aminoglycoside-induced nephrotoxicity.
Answer to Question 2
ANS: C
The risk of renal damage is increased by concurrent therapy with other nephrotoxic agents, such as amphotericin B, cephalosporins, vancomycin, and aspirin.
This patient should be monitored for ototoxicity.
The patients with UTI and pyelonephritis are not at risk for nephrotoxicity, because nothing indicates kidney damage.