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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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Recent studies have shown that the number of medication errors increases in relation to the number of orders that are verified per pharmacist, per work shift.
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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.