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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Illness; diuretics; laxative abuse; hot weather; exercise; sweating; caffeine; alcoholic beverages; starvation diets; inadequate carbohydrate consumption; and diets high in protein, salt, or fiber can cause people to become dehydrated.
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In 1886, William Bates reported on the discovery of a substance produced by the adrenal gland that turned out to be epinephrine (adrenaline). In 1904, this drug was first artificially synthesized by Friedrich Stolz.
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Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.