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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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There are more nerve cells in one human brain than there are stars in the Milky Way.
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The average office desk has 400 times more bacteria on it than a toilet.
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There are more sensory neurons in the tongue than in any other part of the body.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.