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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.

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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).

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Of the estimated 2 million heroin users in the United States, 600,000–800,000 are considered hardcore addicts. Heroin addiction is considered to be one of the hardest addictions to recover from.

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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.

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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.

EEG recordings showing the differences between normal, absence seizure, and generalized tonic–clonic EEG recordings showing the differences between normal, absence seizure, and generalized tonic–clonic
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Gaussian surface in the absence of a dielectric Gaussian surface in the absence of a dielectric
Predators adapt to extreme water pressure and the absence of light Predators adapt to extreme water pressure and the absence of light
The enthalpy change for converting 10.0 g of ice at -25.0 C to water at 80.0 C is ________ kJ. ... The enthalpy change for converting 10.0 g of ice at -25.0 C to water at 80.0 C is ________ kJ. ...
If 0.40 mol of NaN3 reacts completely in the reaction shown below, then ________ L of N2 will ... If 0.40 mol of NaN3 reacts completely in the reaction shown below, then ________ L of N2 will ...
Video: Digestive System Animation

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