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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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For pediatric patients, intravenous fluids are the most commonly cited products involved in medication errors that are reported to the USP.
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Since 1988, the CDC has reported a 99% reduction in bacterial meningitis caused by Haemophilus influenzae, due to the introduction of the vaccine against it.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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There can actually be a 25-hour time difference between certain locations in the world. The International Date Line passes between the islands of Samoa and American Samoa. It is not a straight line, but "zig-zags" around various island chains. Therefore, Samoa and nearby islands have one date, while American Samoa and nearby islands are one day behind. Daylight saving time is used in some islands, but not in others—further shifting the hours out of sync with natural time.