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The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.

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Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%

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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.

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More than 30% of American adults, and about 12% of children utilize health care approaches that were developed outside of conventional medicine.

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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).

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