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| Description: Checkpoint genes in action. Radiation damaged the DNA inside this nucleus. (A) Green dots pinpoint the location of the product of a gene called 53BP1; (B) red dots show the location of the BRCA1 gene product. Both proteins have clustered around the same chromosome breaks in the same nucleus; both function to recruit DNA repair enzymes. The integrated action of these and other checkpoint gene products blocks mitosis until the DNA breaks are fixed. Picture Stats: Views: 132 Filesize: 238.34kB Height: 885 Width: 2101 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=48921 |