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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.

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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.

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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.

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In 1864, the first barbiturate (barbituric acid) was synthesized.

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The immune system needs 9.5 hours of sleep in total darkness to recharge completely.

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