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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.

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It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.

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There are over 65,000 known species of protozoa. About 10,000 species are parasitic.

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After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.

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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.

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