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| Description: (a) With normal iodine intake, as shown on the left, T4 and T3 levels inhibit TSH secretion. Without enough iodine, as shown on the right, less T4 and T3 are synthesized and the TSH level increases. This leads to enlargement of the thyroid gland. (b) An extreme example of an enlarged thyroid gland, or goitre, caused by iodine deficiency.
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