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| Description: Aldosterone stimulates the Na+/K+-ATPase activity of distal tubule cells on the side facing the interstitial fluid (the basolateral membrane). This activity creates an osmotic gradient, as three Na+ ions are reabsorbed from the filtrate for every two K+ ions secreted into it. Water then leaves the tubule by osmosis. The net effect is reabsorption of Na+ ions and water, and secretion of K+ ions, which are excreted in the urine. Na+ ions and water enter the peritubular capillaries and are carried away in the bloodstream.
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