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| Description: This cartoon shows how a change in reverse transcriptase's active site might enable it to recognize AZT as an imposter. (b) This image shows the large groove in the reverse transcriptase enzyme where the substrate (RNA) binds. (c) The red spheres on this image indicate the locations of amino acid substitutions correlated with resistance to AZT. Note that they are localized in the enzyme's groove, or active site. From Cohen (1993).
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