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| Description: Niwa et al. (2010) infused a siRNA that prevented the expression of DISC1 in progenitor cells in the ventricular zone of fetal mice. Although neurons in the prefrontal cortex appeared normal after birth, they developed abnormalities in dendritic spines of these neurons after puberty that led to behavioral abnormalities resembling those of schizophrenia. In humans, the symptoms of schizophrenia usually emerge after puberty.
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