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| Description: The diagram explains the differential effects of a partial agonist in regions of high and low concentrations of the normal ligand. Numbers beneath each receptor indicate the degree of opening of the ion channel: 1.0 = fully open, 0.5 = partially open, 0.0 = fully closed. Partial agonists decrease the mean opening when the extracellular concentration of the neurotransmitter is high and increase it when the extracellular concentration of the neurotransmitter is low.
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