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| Description: The diagram illustrates patterns of the stages of sleep of a normal subject and of a patient with major depression. Note the reduced sleep latency, reduced REM latency, reduction in slow-wave sleep (stages 3 and 4), and general fragmentation of sleep (arrows) in the depressed patient. (From Gillin, J. C., and Borbély, A. A. Trends in Neurosciences, 1985, 8, 537–542. Reprinted with permission.)
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