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| Description: Rats that spent 6 weeks in total darkness showed apoptosis (cell death) in the NE neurons of the locus coeruleus, DA neurons of the ventral tegmental area, and 5-HT neurons of the raphe nuclei. The graph shows the number of terminal buttons in the prefrontal cortex from neurons in each of these areas after the 6-week period. [Based on data from Gonzalez and Aston-Jones (2006, 2008).]
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