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Description: The graph shows correlation between activation of the hypothalamus and orbitofrontal cortex (OFC) and the amount that subjects ate after receiving intravenous infusions of PYY or saline. On saline days, high activity of the hypothalamus predicted increased food intake. On PYY days, high activity of the OFC predicted decreased food intake. (Data from Batterham, R. L., ffytche, D. H., Rosenthal, J. M., et al. Nature, 2007, 450, 106–109.)
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