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| Description: The NMDA receptor is a neurotransmitter- and voltage-dependent ion channel. (a) When the postsynaptic membrane is at the resting potential, Mg2+ blocks the ion channel, preventing Ca2+ from entering. (b) When the membrane is depolarized, the magnesium ion is evicted. Thus, the attachment of glutamate to the binding site causes the ion channel to open, allowing calcium ions to enter the dendritic spine.
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