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| Description: Advanced Alzheimer’s disease is marked by significant loss of both gray and white matter throughout the brain. The brain of a person with Alzheimer’s disease typically has a large buildup of plaques of a protein called amyloid beta, which kills nerve cells. Also, tau proteins maintain the structure of nerve cells in the normal brain; these proteins are often found to be defective in the Alzheimer’s brain, resulting in neurofibrillary tangles.
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