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Catalytic core of sirtuins is evolutionarily conserved

Catalytic core of sirtuins is evolutionarily conserved
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Description: X-ray crystal structures of the catalytic cores of sirtuins from:

Yeast
Archaea
eubacterium
Human
yeast Hst2 sirtuin with bound acetylated peptide substrate and carba-NAD+, a substrate analog

Show a high degree of structural similarity.

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Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34044
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