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| Description: A high NAD/NADH ratio, in response to low nutrients (fasting), activates SIRT1 to deacetylate PGC-1 upregulating its transcriptional coactivator function. Tissue-specific transcriptional activation programs result in increased gluconeogenesis (liver) and increased fatty acid oxidation (skeletal and heart muscle). Picture Stats: Views: 313 Filesize: 72.38kB Height: 452 Width: 416 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34045 |