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The metabolic abnormalities in diabetes

The metabolic abnormalities in diabetes
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Description: The insulin deficiency blocks the uptake of glucose into muscle and adipose tissue and reduces glucose catabolism in all tissues.

Proteolysis in muscle and lipolysis in adipose tissue are enhanced.

In the liver, gluconeogenesis from amino acids and citric acid cycle intermediates is stimulated as the cells attempt to remedy the perceived lack of usable glucose, and fatty acid oxidation and ketogenesis are also increased.


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