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A simplified representation of the folding pathway for a protein

A simplified representation of the folding pathway for a protein
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Description:

“U” is the unfolded or denatured state.

“F” is the folded or native state.

“I” “on-pathway” are intermediate states.

Off-pathway states include aggregates and other non-native states that may be kinetic or thermodynamic “dead-ends”

Thus, the paths to these states are generally shown as irreversible.

In fact, not all pathways leading to such states are irreversible.

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