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Binding of 2,3-bisphosphoglycerate to deoxyhemoglobin

Binding of 2,3-bisphosphoglycerate to deoxyhemoglobin
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Description: The binding site, in the central cavity of the HbA tetramer is lined with eight positively charged groups that help bind the negatively charged 2,3-BPG molecule.

Note the His residues (b143) that are replaced by Ser in fetal hemoglobin (HbF).

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Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34130
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