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Sickle-cell hemoglobin

Sickle-cell hemoglobin
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Description: a) Molecules of sickle-cell Hb tend to aggregate, forming long fibers.

b) An electron micrograph of one sickle-cell fiber.

c) A computer-graphic depiction of one fiber.

A schematic model of fiber formation. DeoxyHb S molecules lock together to form a two-stranded cluster because Val 6 in the b chain of one Hb molecule fits into a pocket in an adjacent molecule.

Interaction of these two-stranded structures with one another produces the multistrand fibers shown in (a) and (b).

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