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| Description: a) The desirable features for each component of the immunoconjugate: targeting antibody, linker, and cytotoxic drug. b) Common sites of attachment of drugs to the antibody constant regions are shown as orange spheres. The tumor-specific antigen binding sites are shown in green and yellow. c) A schematic of the immunoconjugate. The acid-labile hydrazone linker is highlighted in green, but linker is stable in circulation in blood (pH 7.4); but, is cleaved in the acidic environment of the endosome following endocytosis into the tumor cell. Picture Stats: Views: 286 Filesize: 186.49kB Height: 819 Width: 300 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34145 |